Posted by fires on December 27, 2005, at 14:03:55
In reply to Re: Lamictal and Folic Acid » fires, posted by Larry Hoover on December 27, 2005, at 12:41:09
> > > "Folate concentrations were also reduced in male rats given repeated oral doses of lamotrigine. Reduced concentrations were partially returned to normal when supplemented with folinic acid."
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> > > Linkadge
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> > That's the exact text that I found on some site -maybe rxlist. I remember it because of the use of the term "folinic acid".
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> > I take 1200 mcg of folic acid per day + weekly nascobal (B-12) and I still have homocysteine levels at the high end of normal. I'm glad I'm not a rat.
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> > Thanks
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> You don't mention pyridoxine (B6). Folate/B12/B6 work together. The commonly used pyridoxine hydrochloride may be ineffective in some people, due to poor phosphorylation, so some people find P-5-P (pyridoxal-5-phosphate) more useful. Also, high niacin intake can provoke hyperhomocysteinemia in some individuals. It becomes a matter of balancing hyperlipidemia against hyperhomocysteinemia, if you're also using niacin as a drug.
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> Lar
>I take some B6. Pretty sure its the hydrochloride type. I split a "super" multiple B tab into 4 pieces do the the outrageously high doses. I'm wondering what dose of B6 is used. I'm aware that too high of a dose can lead to neuro. problems.
I had problems with the Niacin flush at higher doses, so I take only what is in the piece of the multiple B.
poster:fires
thread:589643
URL: http://www.dr-bob.org/babble/20051221/msgs/592467.html