Psycho-Babble Medication | about biological treatments | Framed
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Re: Tricyclics and anhedonia

Posted by neuroman on November 8, 2005, at 10:24:48

In reply to Re: Tricyclics and anhedonia, posted by Squiggles on November 8, 2005, at 9:38:39

Hi again,

I agree with everything you said. How a particular substance effects an individual depends on that person's biology. With me I've found that I've become very sensitive to meds that effect ion channels and/or the release of glutamate. (i.e. elavil, neurontin, lamictal) These meds seem to effect me at much lower doses than most people. And I have a horrible time tying to stop them. I think this reflects a possible sensitization of some part of my nervous system and I think this sensitization has to do with the NMDA receptor. I can't prove it yet but I'm trying. One way I'm going to attempt to address this is by raising my very low dopamine levels. Dopamine antagonizes the NMDA receptor, so in effect, low dopamine levels may be responsible for the "over-active" NMDA receptors. Anyway, it's become my life's mission to find a doctor to work with who is knowledgable in neuropsychopharmacology. Not an easy task.

By the way, thanks for the Preskorn tip. Not only have I visited the site, I've printed out his entire book. :-)





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