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Re: Tricyclics and anhedonia

Posted by neuroman on November 8, 2005, at 9:25:07

In reply to Re: Tricyclics and anhedonia, posted by Squiggles on November 8, 2005, at 7:21:46


> Unfortunately, there is not much choice
> right now for severe depression- it's either
> the Tri way or the highway.

I hear ya'. No doubt about it, it did help my depression. I wish I had taken a "cleaner" one like desiprimine. More importantly, I wish I had tapered off of it a lot more slowly, even though I did taper more slowly than they say is necessary. I felt physically horrendous for months after I stopped. I think the withdrawal caused some excitotoxic damage to my system. I've heard adding bupropion has helped some people taper off of some of the tricyclics more easily. Wish I had known that at the time...

> Dopamine - yes i have heard it makes you
> happy,

Dopamine transmission increases in certain parts of the brain when we desire something or when we expect a reward or are having feelings of anticipation. If the desire is met or the reward attained than dopamine levels stay high and we feel good. If the desire is not met or the reward is not attained than dopamine levels drop off. We have a word for this..."frustration". This is a huge simplification of the process but it does make sense. At least to my screwed up brain. :-)





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