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How long for SSRI-induced apathy to clear?

Posted by Laurie Beth on August 30, 2005, at 20:33:03

In reply to Re: How I feel on high-dose SSRIs » Smith562, posted by ed_uk on August 29, 2005, at 3:20:36

I am experiencing post-partum apathy and anhedonia that I hope (based on a prior experience while on 300 mg for several years a few years ago) is caused largely by being on high dose of Zoloft. Over the past two months, I have been slowly tapering off the Zoloft - was at 50 mg a month ago, now at 12 mg, will be off completely within a week. As I've decreased, I think I've been experiencing much less sleepiness and maybe 25% less apathy and anhedonia (varies from day to day in no pattern that I can discern), but I'm crossing my fingers that eventually I will feel much better.

If the Zoloft is actually causing these problems, how long might I expect to keep seeing improvement after going off completely? I did see at least one case report in which the woman's apathy resolved completely 1 month after going off the SSRI. I know that the Zoloft should be out of my brain within 16 days after stopping (according to pdoc), but I imagine that other cascasing effects (dopamine increase?) might take much longer.

Any experiences? Or even speculation?

I may regret saying this later, but it seems now that anxiety, irritability, whatever, would be better than this.

Thanks.


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poster:Laurie Beth thread:544795
URL: http://www.dr-bob.org/babble/20050827/msgs/548914.html