Posted by zeugma on September 1, 2005, at 6:38:13
In reply to Re: How I feel on high-dose SSRIs, posted by Dave001 on September 1, 2005, at 1:31:10
I gave up trying to speculate from biochemistry a
long time ago. The more that I learn, the more I appreciate how VERY
little is known about human biology, especially the brain.>>
I agree. I was simply repeating the researcher's speculation that dopaminergic rather than serotonergetic dysregulation might be at the core of such disorders that are provably nonresponsive to fluoxetine. Pharmacological dissection is a very weak tool for getting insight into the mechanism of CNS disorders. But it is nonethelesss used by researchers, which shows there's so little to go on otherwise.