Posted by linkadge on August 19, 2005, at 20:28:36
In reply to Re: Remeron blocks SSRI side effects, posted by 4WD on August 19, 2005, at 15:51:09
"If you weren't taking an SSRI, just the Remeron alone, what would be the effect of this antagonism at the different 5HT sites?"
I guess it depends on the baseline activation of the receptors. Since Remeron does increase serotonin release via alpha-2 antagonism, it may block some of that serotonin and prevent side effects.
If the 5-ht2a receptor is blocked excessivly, it can cause short term memory problems. If the 5-ht2c receptor is blocked excessivly you can experience obsessivness, and seizures. I don't know the side effects of excessive 5-ht3 receptor antagonism.
Personally, the magic dose of remeron for SSRI augmentation was 7.5 mg, which was 1/4 of a tablet.
Linkadge
poster:linkadge
thread:543903
URL: http://www.dr-bob.org/babble/20050816/msgs/544034.html