Posted by 4WD on August 19, 2005, at 15:51:09
In reply to Re: Remeron blocks SSRI side effects, posted by linkadge on August 19, 2005, at 15:19:12
> Blocking the 5-ht2a receptor can block insomnia, physical and emotional anxiety, and cortisol release.
>
> Blocking the 5-ht2c repceot can block agiation, akathesia, loss of appetite, and anorgazmia.
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> Blocking the 5-ht3 receptor can prevent nausia and GI upset. 5-ht3 receptor antagonists also seem to have a degree of anti-anxiety effect.
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> Blocking the 5-ht2a/c receptors also increases frontal cortex norepinephrine and dopamine release, which could offset apathy produced by SSRI's.
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> The NE-Alpha-2 angatonist is more related to the clinical action of mirtazapine. This action increases serotonin and norepinephrine release.
> This action might add AD efficacy but would not specifically reduce and SSRI side effects.
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> Linkadge
>
>If you weren't taking an SSRI, just the Remeron alone, what would be the effect of this antagonism at the different 5HT sites?
Just thought of that...
Marsha
>
poster:4WD
thread:543903
URL: http://www.dr-bob.org/babble/20050816/msgs/543923.html