Posted by linkadge on June 19, 2005, at 15:16:57
In reply to Re: Who knows the drug synergy mechanism?, posted by SLS on June 19, 2005, at 8:46:59
It is proposed by some that the theraputic action of SSRI's is due to the activation of the post-synaptic 5-ht1a receptors. Desensitization of the presynaptic autoreceptors may just lead to more post synaptic activity.
I guess the problem with gepirone was that it is more potent for the presynaptic 5-ht1a autoreceptors than the post synaptic receptor.
This may/may not lead to adaptive changes, who knows.One study found a very robust and fast acting AD effect with the combination of pindolol (presynaptic autoreceptor antagonist) and buspar for its post synaptic agonism, in which case presynaptic desensitization would not be necessary.
Linkadge
poster:linkadge
thread:514944
URL: http://www.dr-bob.org/babble/20050617/msgs/515558.html