Posted by linkadge on June 18, 2005, at 23:45:22
In reply to Re: Who knows the drug synergy mechanism? » linkadge, posted by ixus on June 18, 2005, at 22:47:12
Some of the theory is sound, some is not.
I think the reason the drugs f'd us up is more related to the fact that the drugs activate the "feel crappy" receptors just as potently as they activte the "feel good" receptors.
When taking an SSRI, you have to tolerate 5-ht1d,5-ht2a,5-ht2b,-5ht2c,5-ht3,5-ht7 etc activation just to get some 5-ht1a activation.
5-ht1d activation = apathy
5-ht2a activation = anxiety, paranoia, cortisol
issues, melatonin release
problems, migrane, visual
disturbances.
5-ht2b activation = sleep disturbances
5-ht2c activation = agitation/agression, sexual
side effects, less NAA dopamine, movement issues etc.
5-ht3 activation = Social phobia, anxiety, nausia
GI upset, manic behavior.
5-ht7 activation = memory consolidation issues ?
It's really messed up.
Linkadge
poster:linkadge
thread:514944
URL: http://www.dr-bob.org/babble/20050617/msgs/515329.html