Posted by ixus on June 18, 2005, at 22:47:12
In reply to Re: Who knows the drug synergy mechanism?, posted by linkadge on June 18, 2005, at 16:46:14
> Contrary to what this article suggests, I think that AD mechanisms can be very diverse.
> Even though d2 transmission would be dampened after olanzapine treatment, 5-ht1a transmission would be indirectly enhanced. This would add to the agonistic properties of fluoxetine for the 5-ht1a.
> This is just an idea, but 5-ht1a agonists are antidepressants.
I am aware of dopamine and serotonin reverse mechanism, but apparently one cannot expect that olanzapine enhances 5-ht1a transmission. This is your own theory which is not supported by either theoretical or experimental research. On which basis do you suggest that 5-HT1a would be indirectly enhanced?
I think we are all messed by f*cked up pharmacy market :-)
It may be that no one knows the explanation, the things may actually work, but why they try to create theory that is not based on anything?