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Re: Nardil-why only this drug is a GABA transamina » Chairman_MAO

Posted by cache-monkey on May 7, 2005, at 16:16:34

In reply to Re: Nardil-why only this drug is a GABA transamina » cache-monkey, posted by Chairman_MAO on May 7, 2005, at 13:10:54

Thanks for the info! I did a quick search on SSDH, and the relationship between SSADH inhibition and GBH elevation is definitely intriguing.

~cache-monkey

> Well, you don't want to block Na+ channels for no particular reason because that tends to produce a cognitive slowing, emotional blunting, etc., esp. for those who don't have a strong need for such an effect, e.g. bipolars.
>
> SSADH is succinic semialdehyde dehydrogenase. It is one of two enzymes involved in GABA catabolism (the other is GABA-T). I wish I had more to tell you, but I've only recently started to figure out the details of this for myself recently.


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