Posted by cache-monkey on May 7, 2005, at 1:18:30
In reply to Re: Nardil-why only this drug is a GABA transamina » pro_social_soon, posted by Chairman_MAO on May 6, 2005, at 8:29:15
Hey Chairman_Mao,
A couple of questions for you: What's SSADH? Also, what is the drawback of blocking the voltage-gated sodium channels "for our purposes" (presumably social anxiety?) ?
Thanks,
cache-monkey
> -Depakote is an SSADH inhibitor, and also a GABA-T inhibitor at high doses. It also induces glutamic acid decarboxylase to increase GABA synthesis. Unfortunately (for our purposes), it's an Na+ blocker, and also has a whole host of side effects that make it really unpleasant to take for most people.
>
> -Sabril (vigabatrin) is an irreversible GABA-T inhibitor, but it can cause vision defects that may be irreversible.
>
> -Gastrodin, a component monomer of gastrodia elata tuber extract, is an SSADH inhibitor, which has a similar effect to a GABA-T inhibitor. It also may inhibit GABA-T via an indirect mechanism at higher doses.
>
> --Vanillin is a low-potency GABA-T inhibitor (3g/day in divided doses is a good dose to try
>
> If any of the information here is incorrect, please correct me; I think it's all correct, however.
>
poster:cache-monkey
thread:494405
URL: http://www.dr-bob.org/babble/20050504/msgs/494790.html