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Re: Nardil-why only this drug is a GABA transamina » pro_social_soon

Posted by Chairman_MAO on May 6, 2005, at 8:29:15

In reply to Nardil-why only this drug is a GABA transaminase.., posted by pro_social_soon on May 6, 2005, at 5:55:09

-Depakote is an SSADH inhibitor, and also a GABA-T inhibitor at high doses. It also induces glutamic acid decarboxylase to increase GABA synthesis. Unfortunately (for our purposes), it's an Na+ blocker, and also has a whole host of side effects that make it really unpleasant to take for most people.

-Sabril (vigabatrin) is an irreversible GABA-T inhibitor, but it can cause vision defects that may be irreversible.

-Gastrodin, a component monomer of gastrodia elata tuber extract, is an SSADH inhibitor, which has a similar effect to a GABA-T inhibitor. It also may inhibit GABA-T via an indirect mechanism at higher doses.

--Vanillin is a low-potency GABA-T inhibitor (3g/day in divided doses is a good dose to try

If any of the information here is incorrect, please correct me; I think it's all correct, however.


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URL: http://www.dr-bob.org/babble/20050504/msgs/494442.html