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Re: Reuptake Inhibitors and MAO decrease? SLS

Posted by cache-monkey on May 6, 2005, at 1:02:37

In reply to Re: Reuptake Inhibitors and MAO decrease?, posted by SLS on May 5, 2005, at 18:33:46

Hi Scott,

Well, I guess I'm wondering about what happens when discontinuing an SSRI. MAO might have adjusted upward a little bit. Removing the reuptake inhibitor might leave you worse off for a time until MAO adjusts back down. I could imagine a class of people who are slow to adjust and so get rebound depression.

Pure speculation on my part, though. (And a convenient way to explain my mental health progression.)


> > Up the board a ways, Elroy wrote the following about SSRIs: << The problem with this approach is that these drugs DO NOT increase serotonin levels and in fact deplete reserves of the [neurotransmitter]. This occurs because the SSRI class drugs cause an increase in an enzyme called MAO It is common for people to experience only temporary improvement due to this effect. >>
> I've never heard of this. That doesn't mean that there doesn't exist written material about it, though. My knee-jerk reaction is to say that the magnitude of reuptake inhibition outweighs any increase in MAO activity that an SSRI might produce.
> - Scott




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