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Re: Reuptake Inhibitors and MAO *increase*?

Posted by cache-monkey on May 6, 2005, at 1:04:28

In reply to Reuptake Inhibitors and MAO decrease?, posted by cache-monkey on May 5, 2005, at 13:33:31

Oops, what I meant to say was increase... i.e. MAO goes up in the presence of an uptake inhibitor.

> Up the board a ways, Elroy wrote the following about SSRIs: << The problem with this approach is that these drugs DO NOT increase serotonin levels and in fact deplete reserves of the [neurotransmitter]. This occurs because the SSRI class drugs cause an increase in an enzyme called MAO It is common for people to experience only temporary improvement due to this effect. >>
> I'm wondering whether there's any truth to this statement. E.g. have there been any studies showing this link?
> Maybe I'm just paranoid, but I feel like my one experience with reuptake inhibitors (Wellbutrin + Celexa) left me worse off after withdrawing.
> Would the converse of this be that MAOIs increase stores and production of neurotransmitters? Is that maybe why MAOIs work better for refractory and recurrent depression?
> Input greatly appreciated,
> cache-monkey




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