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Reuptake Inhibitors and MAO decrease?

Posted by cache-monkey on May 5, 2005, at 13:33:31

Up the board a ways, Elroy wrote the following about SSRIs: << The problem with this approach is that these drugs DO NOT increase serotonin levels and in fact deplete reserves of the [neurotransmitter]. This occurs because the SSRI class drugs cause an increase in an enzyme called MAO It is common for people to experience only temporary improvement due to this effect. >>

I'm wondering whether there's any truth to this statement. E.g. have there been any studies showing this link?

Maybe I'm just paranoid, but I feel like my one experience with reuptake inhibitors (Wellbutrin + Celexa) left me worse off after withdrawing.

Would the converse of this be that MAOIs increase stores and production of neurotransmitters? Is that maybe why MAOIs work better for refractory and recurrent depression?

Input greatly appreciated,
cache-monkey


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URL: http://www.dr-bob.org/babble/20050504/msgs/494113.html