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Re: Desipramine » ed_uk

Posted by zeugma on January 27, 2005, at 13:42:48

In reply to Re: Desipramine » zeugma, posted by ed_uk on January 27, 2005, at 13:08:18

> Hi Z!
>
> >The antihistamine effect of NOR is also good for 'sleep hygiene' (i.e. it makes sure I get to sleep on time, and this is crucial for me). Not to mention, it helps my allergies.
>
> The antihistamine effect might worsen your daytime drowsiness though. Also, it is possible that the 5-HT2 antagonism from nortriptyline is worsening your daytime drowsiness. You may prefer desipramine!
>

that's true. although to be honest I don't feel more drowsy during the day on nortriptyline than I did on nothing at all. And curiously, I felt less tired on 100 mg nortrip than I did on lower dosages. Although that's probably because I was able to stay asleep better.

> If you took desipramine instead of nortriptyline you could always take a short-acting sedative antihistamine to help you sleep. You could treat your allergies with a non-sedating antihistamine. Although desipramine is generally only modestly effective for most forms of anxiety, it is sometimes very effective in blocking panic attacks. If you find nortriptyline to be anxiolytic it is quite possible that you might also benefit from desipramine.


True. But I wonder whether desipramine would have the same effect on ADD as Strattera. I suppose there's only one way to find out.
> RE amphetamines.
>
> To be honest, there doesn't appear to be any definate consensus on whether methylphenidate is more or less likely than the amphetamines to cause cardiovascular side effects.
>
> Adderall causes more cardiovascular side effects than Dexedrine so it would not be a good choice for you. If you took Dexedrine immediate release you could adjust your regimen so that your plasma concentration of dextroamphetamine was low at meal times- this may reduce the risk of weight loss. A beta blocker may be useful for cardiovascular side effects. What cardiovascular side effects did you experience with methylphenidate?
>
> Ed.
>
rapid heartbeat, chest pains, sudden dizzy spells after exertion, which lessened after lowering the nortrip dosage. also my heart rate was much more rapid at peak levels of Rit (late morning/early afternoon) causing fluctuations that could not have been good for my system.

your idea about dexedrine is a good one and helpful. dexedrine is also supposed to be less anxiogenic than adderall, and frankly i can't elevate my anxiety level much past where I am now.

thanks for the info. I am seeing pdoc today so it is especially valuable to have this knowledge.

-z


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poster:zeugma thread:446337
URL: http://www.dr-bob.org/babble/20050124/msgs/448704.html