Posted by zeugma on January 27, 2005, at 12:44:44
In reply to Re: Desipramine and ADD » zeugma, posted by ed_uk on January 27, 2005, at 11:57:35
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> No!
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> Have you ever tried desipramine?
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> Hey Ed!I've brought up desipramine to my pdoc but he says that it is nearly identical in clinical effect to nortriptyline. The only difference according to him is that higher dosages of desipramine are usually needed to get an AD effect. This is interesting in light of the fact that DMI is about four times more potent at its putative site of action than nortrip. What I can say, if Dement and associates are correct and NE reuptake inhibition is the mechanism by which cataplexy is controlled (leaving MAOI's out of the question for the moment), then 100 mg nortriptyline does the trick, and has a reputation for being more anxiolytic to boot. The antihistamine effect of NOR is also good for 'sleep hygiene' (i.e. it makes sure I get to sleep on time, and this is crucial for me). Not to mention, it helps my allergies.
-z (on his 3rd pot of half-caffeinated coffee, playing raucous music at extremely high volumes to ward of drowsiness)
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poster:zeugma
thread:446337
URL: http://www.dr-bob.org/babble/20050124/msgs/448661.html