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Re: SSRI/dopamine antagonism » Mistermindmasta

Posted by zeugma on December 15, 2004, at 13:33:30

In reply to Re: SSRI/dopamine antagonism, posted by Mistermindmasta on December 15, 2004, at 1:11:38

this part is true also:

That's pretty goofy that the serotonin receptor regulates the dopamine receptor in the striatal region, but quite interesting. I can think of one improbable possibility for this: in the PFC, there is no DAT. The NET acts as the reuptake mechanism for DA.

The NET clears most extracellular DA from the PFC. This is why Strattera is hypothesized to work for ADHD (it does, although with many qualifications) and why the TCA's have been secon-line meds for ADHD for decades despite their being for the most part sedating meds.

The NET actually has a higher affinity for DA than for NE.


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poster:zeugma thread:428740
URL: http://www.dr-bob.org/babble/20041211/msgs/429937.html