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Re: SSRI/dopamine antagonism

Posted by Mistermindmasta on December 15, 2004, at 1:11:38

In reply to Re: SSRI/dopamine antagonism » linkadge, posted by raybakes on December 12, 2004, at 7:41:16

> > Actually, if I discontune the SSRI, the tremors and facial grimaces, shoulder rotations etc get worse !
> >
> > It was made aware to me that if sometimes a psycotropic that causes dystonia can cause more when the drug is removed.
> >
>
> Looking at several articles and abstracts it seems possible that SSRIs block the action of SERT but the body compensates by upregulating DAT which has some serotonin activity but screws up dopamine.
>
> Coming off SSRIs reactivates SERT, which like DAT has activity for both serotonin and dopamine - so poor dopamine gets zapped again!
>
>
> "Results from our DA uptake experiments indicate that SERT is an important modulator of both 5-HT and DA uptake and that ~40% of the DA uptake observed in striatum is due to promiscuous SERT activity."
>
> Do you think that could be an explaination or is something else happening?
>
> Ray
>
>

That's pretty goofy that the serotonin receptor regulates the dopamine receptor in the striatal region, but quite interesting. I can think of one improbable possibility for this: in the PFC, there is no DAT. The NET acts as the reuptake mechanism for DA. Similarly, I hypothesize that when a certain percentage of SERT are blocked, the DAT actually begins to reuptake serotonin to make up for less SERT activity. That's probably a stretch since NE and DA are much more chemically similar than 5-HT and DA. But who knows...


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poster:Mistermindmasta thread:428740
URL: http://www.dr-bob.org/babble/20041211/msgs/429759.html