Posted by raybakes on December 12, 2004, at 7:41:16 [reposted on December 13, 2004, at 3:10:03 | original URL]
In reply to Re: SSRI/dopamine antagonism, posted by linkadge on December 11, 2004, at 16:31:31
> Actually, if I discontune the SSRI, the tremors and facial grimaces, shoulder rotations etc get worse !
>
> It was made aware to me that if sometimes a psycotropic that causes dystonia can cause more when the drug is removed.
>
Looking at several articles and abstracts it seems possible that SSRIs block the action of SERT but the body compensates by upregulating DAT which has some serotonin activity but screws up dopamine.Coming off SSRIs reactivates SERT, which like DAT has activity for both serotonin and dopamine - so poor dopamine gets zapped again!
"Results from our DA uptake experiments indicate that SERT is an important modulator of both 5-HT and DA uptake and that ~40% of the DA uptake observed in striatum is due to promiscuous SERT activity."Do you think that could be an explaination or is something else happening?
Ray
poster:raybakes
thread:428740
URL: http://www.dr-bob.org/babble/20041211/msgs/428749.html