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Re: How do I know IF I am a slow metabolizer? » gromit

Posted by Larry Hoover on November 21, 2004, at 9:06:57

In reply to Re: How do I know IF I am a slow metabolizer? » jasmineneroli, posted by gromit on November 19, 2004, at 1:59:33

> Maybe this explains why codeine does nothing for me, but vicodin is a stimulant. So much to learn, so little remaining brain cells.
>
> Rick

A critical clue, perhaps. If codeine doesn't work for you, you fall into a group of perhaps even 10% of us, who have trouble with 2D6 drugs. As about one third of all psychotropic meds are at least partially metabolized by 2D6, that's a big problem. If you're innately weak in 2D6, and you take a drug that shuts down (inhibits) 3A4, you can have horrid reactions. Honestly, I think that's why Serzone (nefazodone) can be hepatotoxic.

Knowing I get no pain relief from codeine, I constantly run into problems if I need acute pain treatment and doctors think I'm drug-seeking. But such is life. I calmly explain that codeine does nothing but constipate me, and I need a different opiate. No tylenol 3's for me.

Lar

 

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poster:Larry Hoover thread:417092
URL: http://www.dr-bob.org/babble/20041118/msgs/418571.html