Posted by jasmineneroli on November 19, 2004, at 1:55:14
In reply to Re: How do I know IF I am a slow metabolizer?, posted by Phillipa on November 18, 2004, at 23:52:12
Lar:
This is absolutely fascinating! I'm s'posed to be in bed, loaded up with Tryptophan and snoozing straight throught the night!! But it's just got my mind racing. So many questions.I'm perplexed over apparent contradictions.
According to the tables, Buspirone uses 3A4 only.
Buspirone didn't work for me at all and gave me my usual side effects. Clonazepam works like a hot dam, with no side effects -3A4 only, too! Must be other factors at work here?On the other hand, I believe myself to be unable to tolerate any form of progesterone (2C19 & 3A4)and even low doses of Citalopram give me s/e's (2C19). However, both have a powerful effect on me. (I only need low dose to have a response).So does that mean I'm a good metabolizer of 2C19, or a bad one? (Big effect vs Bad side effects?).
I've had good (effective) responses to both codeine and DM (both 2D6 and 3A4). However, higher doses of codeine give me stomach side effects. I think 3A4 has something to do with gastric side effects???
Ibuprofen has little analgesic effect for me, so does that indicate poor metabolism of 2C9?
Acetaminophen has little effect too, except in high doses(1A2, 2E1 & 3A4 again). Since caffeine does work quickly (1A2 & 3A4) should I assume that the 2E1 in acetaminophen is not being metabolized properly???The tables weren't detailed enough to show interactions between my particular drugs and I'd like to know which enzymes are inhibited/induced by Tryptophan. Do you know another source of info??
In fact, I have been recently thinking, that I'm extremely sensitive to MOST drugs EXCEPT analgesics and hypnotics. (I always need loads of novacaine for numbing, higher sleeping pill doses than the norm, lot's of acetaminophen for pain). I was wondering why. Maybe this CP450 puzzle holds the answer!and Larry, I really do think you should write a book. You have an excellent writing style - varied vocab. etc.etc. :)
Take care
Jas
poster:jasmineneroli
thread:417092
URL: http://www.dr-bob.org/babble/20041118/msgs/417772.html