Posted by King Vultan on November 6, 2004, at 22:58:18
In reply to Re: Wellbutrin + Paxil? » King Vultan, posted by jujube on November 6, 2004, at 13:54:27
> Would the same concern apply to a combination of Anafranil and Celexa? My pdoc just prescribed Anafranil and has told me to reduce my dose of Celexa to 20 mg (from 40 mg) and continue to use it at the same time as the Anafranil. I have never taken 2 ADs at the same time, so I have been a bit worried about this.
>
> Thanks.
>
> Tamara
>
>
Not exactly, because the enzyme interactions between these two drugs are pretty limited. Celexa is only a weak 2D6 inhibitor and is not going to increase the blood plasma levels of the Anafranil appreciably. The only thing I would question is why your pdoc is having you take two SSRIs at once (Anafranil/clomipramine is a tricylic AD, but it is also an SSRI, as it is selective for blocking serotonin reuptake). Was any reasoning given for this?
Todd
poster:King Vultan
thread:411372
URL: http://www.dr-bob.org/babble/20041103/msgs/412754.html