Posted by SLS on November 4, 2004, at 6:17:19
In reply to Re: Wellbutrin + Paxil? » King Vultan, posted by KaraS on November 3, 2004, at 23:56:58
Hi Kara.
Wellbutrin (bupropion) itself is increased by the inhibition of 2B6 by Paxil (not 2D6). Wellbutrin is a weak inhibitor of 2D6, but not a substrate. As Todd indicates, the major metabolite of Wellbutrin, 2-hydroxybupropion is affected by Paxil. It is increased due to the action of Paxil at both 2D6 and 2B6. It is pharmacology active, and thought by some as being more responsible than the parent compound for the therapeutic effect of Wellbutrin. Unfortunately, the seizure risk of Wellbutrin, although generally exaggerated, must still be taken into consideration. I was fine at a dosage of 900mg.
Effexor + Wellbutrin is without these interactions and will not result in increased levels of either drug.
Do you obtain a partial response to either Paxil or Effexor?
- Scott
poster:SLS
thread:411372
URL: http://www.dr-bob.org/babble/20041103/msgs/411479.html