Posted by King Vultan on November 3, 2004, at 23:08:58
In reply to Wellbutrin + Paxil?, posted by KaraS on November 3, 2004, at 22:44:55
> Any reason not to combine these two medications?
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Yes, they're both strong CYP-450 2D6 inhibitors and also substrates of that enzyme (you will not see Wellbutrin listed on every enzyme interaction chart, perhaps because its metabolites are the real problem). Each drug will tend to increase the blood plasma level of the other substantially. While there would not be the lethality concerns in the same sense there would be if one of the drugs were a tricyclic, a person would run some risk of excessive side effects from one or both. Actually, if a tricyclic were involved, you could at least monitor blood plasma levels to see if they were in the therapeutic range, and adjust the dosage accordingly. With Wellbutrin and Paxil, I think a person would be very much in the dark as to what is really going on.Todd
poster:King Vultan
thread:411372
URL: http://www.dr-bob.org/babble/20041103/msgs/411383.html