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Re: Seroquel/Remeron

Posted by Sad Panda on October 26, 2004, at 22:51:10

In reply to Re: Seroquel/Remeron » King Vultan, posted by jboud24 on October 26, 2004, at 15:56:46

> So serotonin 2a blockade is involved in increased appetite? I thought that it was the 5-HT3 blockade (ala granisetron) that by inversely getting rid of nausea was a pro-hunger mechanism. I know that the histaminergic action has also been implicated in the pro-hunger effects, but I didn't know the 2a receptor was. It would be interesting to know whether or not a drug with a more pure 2a antagonism would cause increased hunger.
>
> I also thought that dopaminergic blockade caused some level of sedation or somnolence. Am I wrong about that? I'm just saying maybe giving Seroquel a shot could work for decreasing the hunger thing while still providing some relief from insomnia. I've only taken Seroquel once, but it was definitely sedative in a way not akin to what I had been used to with Remeron. If only Remeron came without that 5-HT3 receptor blockade I'd like it so much more.
>
> Justin
>

It's more likely to be serotonin 2C receptor blockade that causes an increase in appetite, unfortunately most things that block 2A also block 2C receptors & to some degree type 3 receptors.

Cheers,
Paul.



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URL: http://www.dr-bob.org/babble/20041024/msgs/407731.html