Posted by King Vultan on October 25, 2004, at 22:51:50
In reply to Remeron has stopped working and I am a monster, posted by cherylann on October 25, 2004, at 22:29:46
> At least according to my family. It's really too bad cuz I had a delicate balance of remeron, klonopin, and fish oil that was working great.
> Now I'm having heart palpitations, painful walking after sitting for a while (which I suspect is from the 30lbs I've gained), HORRIBLE mood swings and severe depression, especially in the mornings.
> After some intensive research, I'm going to ask the doc to let me try cymbalta and because I can't sleep at night, a low dose of seroquel. The reason why I choose this is because I respond so well to tricyclics, but cymbalta only helps with serotonin and norepinephrine. I've read that seroquel helps with dopamine, which is the other chemical tricyclics trigger.
> For anyone out there with more working brain cells than me, does this sound logical? My family is about ready to disown me and I'm desperate.
> Thanks,
> cherylann
Seroquel is an atypical antipsychotic which has differing effects on dopamine. Basically, it is designed to boost dopamine in certain dopamine pathways to counteract the negative effects of blockading dopamine D2 receptors, the latter effect being common to all antipsychotic drugs. In the older, conventional antipsychotics, there were a great many negatives associated with the D2 receptor blockade, such as movement disorders and the dreaded tardive dyskinesia. Atypical antipsychotics such as seroquel are much better this way, but weight gain can unfortunately still be a big problem.Tricyclics mostly just work on serotonin and norephinephrine, as Cymbalta does. Some of them, such as nortriptyline, can indirectly boost dopamine because they utilize the same mechanism atypical antipsychotics use to do this (blockade of serotonin 2A receptors).
Todd
poster:King Vultan
thread:407236
URL: http://www.dr-bob.org/babble/20041024/msgs/407253.html