Posted by King Vultan on October 26, 2004, at 14:19:48
In reply to Seroquel/Remeron » Sad Panda, posted by jboud24 on October 26, 2004, at 12:56:02
>
> > Hi Cherylann,
> >
> > How much Remeron are you taking? If you can't get sleep with Remeron, then Seroquel isn't going to be much use either. If you had success with TCA's, why not go back to them?
> >
> > Cheers,
> > Paul.
>
> Gee, I didn't know Remeron has a dopamie blockading effect like Seroquel. That's a new one on me. I do know, however, that when I was taking Remeron (and still am) 30mgs, that if I skipped out on the Remeron and took Seroquel it had a noticably different sedating action to it. I wouldn't say more sedating, just different sedating. It really might be worth a shot.
>
> Justin
>
>What Panda is talking about doesn't really have anything to do with dopamine, at least not directly, and Remeron does not blockade dopamine D2 receptors to any noteworthy extent. The sedative properties of Remeron are related to its powerful histamine H1 blockade combined with its blockade of serotonin 2A receptors. These two blockades are also largely responsible for the notorious weight gain problems associated with Remeron, the histamine blockade probably being the worse of the two that way. He appears to feel Seroquel is unlikely to be as sedating as Remeron is, which sounds like a reasonable assumption, but I haven't tried either of these drugs and really don't know firsthand how sedating either is. I do think a low dose of Seroquel is probably not as likely to induce weight gain as 30 mg of Remeron, so it may be worth a try, anyway.
Todd
poster:King Vultan
thread:407236
URL: http://www.dr-bob.org/babble/20041024/msgs/407507.html