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Re: Parnate, Morphine, and Trusting Joe Paramedic =)

Posted by Sad Panda on October 14, 2004, at 13:32:48

In reply to Re: Parnate, Morphine, and Trusting Joe Paramedic =), posted by utopizen on October 14, 2004, at 13:05:03

> > Tyramine induced hypertensive crisis are a source of concern, but an antidote can be carried for this(and for SS). Amphetamines aren't totally contraindicated either, Parnate itself is an amphetamine like chemical & Selegiline which is nearly identical to Parnate does actually metabolize into methamphetamine & amphetamine. The only real problem with MAOIs is cough medicines & decongestants such as pseudoephedrine.
> >
> > Cheers,
> > Paul.
> >
>
> Paul, thanks for the clarification. But my pdoc, a Harvard Professor of psychopharmacology, said MAOIs do interact with Demerol, and that's a huge risk if I were to go to the hospital in pain. I've also spoken to ER docs who use the Demerol name like it's a household name in hospitals, even assume that I'm very familiar with it because it's such a widely used drug.
>
> Demerol is used by ER medicine a lot. And both ECT and MAOIs *are* "maybes." There is conflicting evidence that ECT contributes to memory loss, so memory loss is a maybe. And MAOI-induced hypertensive crisis is a maybe as well.
>
> Please, I know you're ready to pull up some Medline abstracts, but I underscore the term "conflicting" evidence for a reason.
>
> Take care, and good luck with your treatment! =)
>
>

You are right, the info I have is from Australian hospitals. Demerol (called Pethidine here) was the most common way to get serotonin syndrome from MAOI's, but more than one injection is normally required. Demerol is rarely used here anymore as it is hardly any beter than codiene, but has numerous disadvantages such as a half life that is too short & neurotoxicity. I am surprised that it is still commonly used where you are.

Cheers,
Paul.



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poster:Sad Panda thread:402677
URL: http://www.dr-bob.org/babble/20041012/msgs/402997.html