Posted by pablo1 on October 7, 2004, at 16:49:08
In reply to Re: Geno....Let's Brainstorm...... » pablo1, posted by iris2 on October 7, 2004, at 15:45:03
I can hardly tell the difference btwn the two but I like amisulpride better somehow it's sweeter, yet more subtle. I couldn't tell the difference between ritalin & adderall either though. Amisulpride is more specially targeted toward the D2 & D3 receptors (though I don't know the significance of those) and it is an agonist meaning it increases DA release. Ameneptine is described as a more broad brush DA reuptake inhibitor meaning it prevents your body from reabsorbing it's already available dopamine.
Ameneptine is shorter acting & I think should not require a week of ramp-up time.
Neither of them seem to be real sensitive to dosage for me. I'm only taking 1/16th of a 200mg amisulpride tab. Because it's so little I snort it but it's not like I get a big rush or anything, it still takes half an hour to feel. I get greedy and want more effect but it's not much different if I take 50 mg (4x that dose) when I was being more careful I felt that a larger dose did make me more stoned & that's how I settled on the 12.5mg. I should emphasize though that even if I take more trying to abuse it, I don't get real obviously stoned. Smoking some pot works much better in that department so I'm trying to relax & be a good boy & just use it therapeutically.
Oh, and I have heard that ameneptine commonly poops out or people develop tolerance pretty quickly like a couple weeks. I hope that doesn't happen with the amisulpride. There was one guy I read who got a cocaine high from 100mg amisulpride which went away after a year. He was being prescribed at 2 or 300 dose for antipsychotic effect but felt that the higher doses were a waste. For what it's worth, he had a history of abusing meth (speed) and while he did enjoy abusing it, it seems he's much happier now and certainly not as abad off as he was abusing the meth, which is a really awful narcotic to abuse.
Then I take 1/4 of a 100mg ameneptine later in the day. I've tried up to 300mg ameneptine with only a slight increase in effect. In fact when I got a second order after running out, I gobbled 300mg & didn't feel anything till later after also taking 100mg of amisulpride & drinking wine.
Oh one more thing... When I ran out, I felt a subtle effect from the amisulpride for at least a week after quitting.
Not sure if any of that helps you but if you don't feel anything it probably means it's not targeting what you need. Although the ameneptine should be more generic, hitting the same spots as the amisulpride plus others but who knows?
> I am on Amisulpride and it helps some but not with adehenia. I took Amineptine the first time it was great but I just tried it again this time with Amisulpride and got no reaction. I took it about a week. I was starting to think it was making the Amisulpride not work. Do you think I should try one more time ( have tried about 5 times since it worked the first time) the Amineptine with the Amisulpride? Perhaps I need to increase the dose to at least 2 tabs a day? Perhaps I need to try it a little longer but the first time I saw a difference within a couple of days.
> Want some opionions.