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Re: A possible explaination.

Posted by linkadge on October 2, 2004, at 8:31:24

In reply to Re: A possible explaination. linkadge, posted by iris2 on October 1, 2004, at 17:32:30

In this case *no*. Amisulpride potently blocks the d2 (but more importantly blocks the d3) receptors. Mirapex on the other hand is a potent d2/d3 agonist.

Mirapex would probably be much better at treating anhedonia (at least theoretically)

The only time atypicals can be good at treating anhendonia is when they are potent d2 blockers but *don't* block the d3 receptor. In this case the blocked dopamine makes its way to the d1/d3 receptors which can help anhedonia.


The only other factor to consider is where the drugs block the receptors. My above assesment is assuming that the drugs block all dopamine receptors throughout the body. Some antipsychotic are preferetial to say lower brainstem dopamine receptors and leave the ones in the nucleus accumbens (pleasure centres) open. So in practice the only way is trial and error. But there is a better chance that mirapex would activate the NAA (neucleus accumbens) and give that reward.


Linkadge


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URL: http://www.dr-bob.org/babble/20041002/msgs/398210.html