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Re: A possible explaination. owensmar

Posted by King Vultan on August 29, 2004, at 22:50:20

In reply to Re: A possible explaination. linkadge, posted by owensmar on August 29, 2004, at 20:19:29

> Another thing for me to think about is that I have galactorrhea (breasts produce small amounts of fluid). I have read that this can be due to dopamine depleting agents (or to a pituitary tumor called a prolactinoma). However, since the galactorrhea started when I started on a/ds in 1986 I wonder whether the increased serotonergic and/or norepineprinergic (is that even a word) receptor activity has somehow caused the dopamine receptors to inactivate or go into hiding, as it were. That would explain my anhedonia - which actually seems to be worse on Effexor. I feel very little on Effexor, can't cry, don't feel grief, etc. as well as not feeling joy or pleasure.(Admittedly I would rather be anhedonic than weeping constantly and imagining possible suicide scenarios.) AT least I think so.

Good try, but "noradrenergic" is the term that seems to be used to refer to norepineprinergic type activity. The term is derived from noradrenaline, which is another word for norepinephrine; likewise, adrenaline and epinephrine are the same thing, giving rise to the analogous term "adrenergic".

If you're on a low dose of Effexor, the effect is almost all serotonergic, which may tend to further deplete dopamine in the pleasure centers of the brain. I also noticed the emotional aloofness on Effexor you describe and would recommend trying something that has a more powerful effect on norepinephrine. This seems to be the neurotransmitter that is most involved with feeling deep emotion, spirituality, and empathy. Well, that's been my experience, anyway.





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