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Re: A possible explaination. linkadge

Posted by jerrympls on October 2, 2004, at 11:12:09

In reply to Re: A possible explaination., posted by linkadge on October 2, 2004, at 8:31:24

> In this case *no*. Amisulpride potently blocks the d2 (but more importantly blocks the d3) receptors. Mirapex on the other hand is a potent d2/d3 agonist.
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> Mirapex would probably be much better at treating anhedonia (at least theoretically)
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> The only time atypicals can be good at treating anhendonia is when they are potent d2 blockers but *don't* block the d3 receptor. In this case the blocked dopamine makes its way to the d1/d3 receptors which can help anhedonia.
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> The only other factor to consider is where the drugs block the receptors. My above assesment is assuming that the drugs block all dopamine receptors throughout the body. Some antipsychotic are preferetial to say lower brainstem dopamine receptors and leave the ones in the nucleus accumbens (pleasure centres) open. So in practice the only way is trial and error. But there is a better chance that mirapex would activate the NAA (neucleus accumbens) and give that reward.
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> Linkadge
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I've been suffering from anhedonia a chronic dysthymia for years. I've been trying to convince doctor after doctor that it's my dopamine/reward centers that are out of whack. Well, about 10 days ago I was diagnosed with Restless Legs Syndrome (RLS) and was put on .125mg of Mirapex with directions to double the dose after a week or so. This past Tuesday I doubled the dose and felt greater relief from the RLS, but I also noticed that I've been more interested in actually *doing* things - talking to friends, cleaning my apt (!), listening to music, working on some computer web projects, etc. All stuff I *had* enjoyed before anhedonia set in years ago. Today's the 3rd day I've felt an increase in motivation, etc., and it's feels good. I can only hope it continues to last!!


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URL: http://www.dr-bob.org/babble/20041002/msgs/398256.html