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Re: To Scott » Denise1904

Posted by SLS on August 24, 2004, at 13:29:03

In reply to Re: To Scott, posted by Denise1904 on August 24, 2004, at 10:54:48

Hi there Humpty Dumpty.

> That sounds great, taking a drug and it putting you back to normal again and then just being able to come off it and still be normal. That's what I want as I feel like Humpty Dumpty who just wants to be put back together again. I just hope there are no withdrawal effects from it. Will you be able to get hold of any from your Psychiatrist?

I have made some preliminary contacts that should help me find mifepristone on a compassionate use basis. Believe it or not, the FDA has placed mifepristone on its "fast track" program for investigation into its use in depression. I guess the data from the initial studies were pursuasive enough.

Your experience with Dothiepin represents a scenario that is far too common. I hope doctors will soon be able to determine who needs to stay on an antidepressant long-term so as not to foster a circumstance of treatment-resistance by multiple exposures to medication.


> How do you know that your HPA axis is off kilter, have you had one of those dexamone (not sure how to spell it) suppression tests

Yup. My DST (dexamethasone suppression test) came back abnormal. Other tests have shown my cortisol levels to be too high.

> and how long have you been taking the Cymbalta?

I am day 5 of Cymbalta. I have been taking only 30mg, which is considered to be lower than what the manufacturer recommends as a starting dose. My doctor is being cautious. I'll defer to his judgment on this. I actually experienced a mood/function lift for a few hours after my first dose. Right now, the only side effect that is emerging is sleepiness. It is significant, though, and would be a real obstacle were it to continue. I think it will pass, though. I'm trying to keep up with a log of my experience with Cymbalta as a thread below listed as "Cymbalta (duloxetine) - report". I'll try to keep the subject line the same, as it gets edited from time to time.

What has been you history with the MAOIs (monoamine oxidase inhibitors)?

Zyprexa really can be a life-saver. I'm glad it did the job for you. I take a small amount of Abilify. I recieved a robust antidepressant effect during the first week. I think it still helps prevent me from reaching the desperate suicidal states that I sometimes experience. The one caveat when using Abilify is that it often produces anxiety and restlessness in the beginning. It usually passes, but it is important to understand that it is a likely startup side effect.


- Scott

 

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