Posted by iris2 on August 20, 2004, at 18:53:31
In reply to Re: Shouldn't there be a limit to this, tried rTMS » iris2, posted by SLS on August 20, 2004, at 17:24:08
> Hi Pest.
>
> :-)
>
> > I do not understand NE/5-Ht so well. Can you elaborate or simply compare it with similar drugs so I can understand it better? Perhaps a link if you have one on the top of your head or under your arm! I know I am a pest.
>
> This will have to be short - sorry. I have a date with the circus.
>
> NE = norepinephrine
> 5-HT = serotonin
>
> Some drugs, like the SSRIs (Prozac, Zoloft, Paxil, Luvox, Celexa, Lexapro), only work on one neurotransmitter - in this case, serotonin. Others work primarily on norepinephrine (desipramine, nortriptyline, reboxetine, maprotiline). Some work on both. Most of the tricyclics and Effexor inhibit the reuptake of both 5-HT and NE, but not always equally. Effexor, in particular, is much more potent on 5-HT than NE. Cymbalta is still biased towards 5-HT, but not as much. It is more balanced. I guess you could say that Cymbalta is a better-balanced version of Effexor. It *might* thus produce an antidepressant effect similar to high dosages of Effexor, but with milder side effects - especially those involving sexual function and apathy. We'll have to see about that.
>
> In general, it is becoming apparant that drugs that work on multiple neurotransmitters are more effective than those that are selective to only one. Effexor, for example, seems to get more people well, gets each person more well, and poops-out less often than the SSRIs.
>
> > Thanks for being you,
>
> That is the nicest thing that anyone can ever say to me. Thank you.
>
> Ditto.
>
> Please don't ever be reluctant to ask questions of anyone here. It's what makes this place work. My explanation was overly simplified, so don't be afraid to dig deeper. Most drugs, even the "selective" ones, are biologically active at sites other than the ones considered to be primary. It is difficult to conclude which properties are essential, and which are unnecessary or undesirable.
>
>
>
> - ScottThanks,
This gets so complicated. I read stuff and there is just so much more involved than what I asked. The effects on dopamine D1 and D2 and so much much more. I was trying to understand some similarities to drugs that worked that I might have taken . I would at some point like to study this more in depth. But I will have to find a starting point.
From what you said it does appear that Duloxetine would probably be a good start. ANd reboxetine did help some also. I was trying to "compare" it with how Parnate works and it was like sudden blindness. It does make sense since none of the several SSRI's I tried did anything at all. Cocaine seems to have done the best but well ...
Don't be a clown!
I missed the ballet. It was a free concert in the park. It is one of the few joys I still get out of life but it rained so I guess they did not have it.
Have fun,
irene
poster:iris2
thread:378449
URL: http://www.dr-bob.org/babble/20040817/msgs/380108.html