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Re: neurontin to zonegran : weight loss, anxiety ? jtevers

Posted by sooshi on July 22, 2004, at 20:59:15

In reply to Re: neurontin to zonegran : weight loss, anxiety ?, posted by jtevers on July 21, 2004, at 20:30:05

I found this in the literature...I remembered reading something about GABA.

"in vitro studies have demonstrated that zonisamide (10-30 ug/mL) suppresses synaptically-driven electrical activity without affecting postsynaptic GABA or glutamate responses (cultured mouse spinal cord neurons) or neuronal or glial uptake of [3H]-GABA (rat hippocampal slices). Thus, zonisamide does not appear to potentiate the synaptic activity of GABA."

Not really sure what that means, but maybe you do! Hope it helps to answer your question,




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