Posted by Sad Panda on February 18, 2004, at 7:23:44
In reply to Re: RITANSERIN - availabe on earth?? » Sad Panda, posted by Chairman_MAO on February 17, 2004, at 10:56:29
> Oh, it didnt occur to me that you meant "serotonin" and not "selective". Personally, I _DETEST_ those acronyms. I believe Shire actually calls Adderall a NDmA, or "Norepinephrine/Dopamine modulating Agent". Uhh, yeah, modulation. That says a lot! How about a "CRaP, or Catecholamine Releaser and Potentiator" Makes about as much sense. I wish pharma companies would stop naming their products as if they were Microsoft. And what the hell is with "Symbyax", anyway? Sounds either like an alien warlord or the name of a prostitute in Gary, Indiana.
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> I believe the difference is that sertraline's Ki is 0.29 for the SE reuptake pump and venlafaxine's is around 10. Thus, you could TOLERATE the dose of venlafaxine to meaningfully inhibit NE reuptake, but the amount of sertraline you'd need for significant DA reuptake would make things quite uncomfortable (or more uncomfortable then venlafaxine, at least, because at 375mg/day, that's not terribly comfortable on all fronts either, mainly libidinal/genital numbness). Am I right here? People seem to think I know a lot, but I'm getting the feeling that you're more knowledeable with some of the technical stuff. I, just seem to have a pretty good intution for knowing how a lot of drugs influence behavior. This is why I am going back to school, so I can hopefully do something with this talent--legally. Do you have a background in this field of any kind?
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>I have no background at all in this stuff, but since it affects me I've taken a big interest in it. I don't know much about anything, but I do know where to find the answers. :) I don't know anything about mood stabilizers/anti-convulsants & the only thing they let BP people have here in Australia is Lithium, so I hope I don't have BP2, I am waiting in a queue for a visit to a pdoc for a proper DX.
I believe you are correct with Venlafaxine's affinity for 5-HT v NE in that it's about 5:1. At 75mg it's just another SSRI, at 300-375mg it starts heavily blocking NE reuptake. I think Sertraline 5-HT v DA maybe as close as that or maybe be more like 10:1 depending on which study you read. Of all the studies & abstracts I have read about about SSRI's, Sertraline is the one that appears to be above average & also seems to be the safest. If Efexor+Remeron is a failure I would like to try Sertaline next, I'd try & cross taper on to it from Efexor.
"libidinal/genital numbness" I have zero libido at 225mg of Venlafaxine, but Remeron (called Avanza here) has returned functionality. If my wife asks for it, I get excited & can perform, but if she doesn't ask, I would never think of sex. It's like Venlafaxine blocks Testosterone from the brain. Something else that truely bugs me is Efexor is spelt with one F here, not two, wierd. :)
Cheers,
Panda.
poster:Sad Panda
thread:313489
URL: http://www.dr-bob.org/babble/20040218/msgs/315047.html