Posted by Chairman_MAO on February 17, 2004, at 10:56:29
In reply to Re: RITANSERIN - availabe on earth?? » Chairman_MAO, posted by Sad Panda on February 16, 2004, at 22:47:42
Oh, it didnt occur to me that you meant "serotonin" and not "selective". Personally, I _DETEST_ those acronyms. I believe Shire actually calls Adderall a NDmA, or "Norepinephrine/Dopamine modulating Agent". Uhh, yeah, modulation. That says a lot! How about a "CRaP, or Catecholamine Releaser and Potentiator" Makes about as much sense. I wish pharma companies would stop naming their products as if they were Microsoft. And what the hell is with "Symbyax", anyway? Sounds either like an alien warlord or the name of a prostitute in Gary, Indiana.
I believe the difference is that sertraline's Ki is 0.29 for the SE reuptake pump and venlafaxine's is around 10. Thus, you could TOLERATE the dose of venlafaxine to meaningfully inhibit NE reuptake, but the amount of sertraline you'd need for significant DA reuptake would make things quite uncomfortable (or more uncomfortable then venlafaxine, at least, because at 375mg/day, that's not terribly comfortable on all fronts either, mainly libidinal/genital numbness). Am I right here? People seem to think I know a lot, but I'm getting the feeling that you're more knowledeable with some of the technical stuff. I, just seem to have a pretty good intution for knowing how a lot of drugs influence behavior. This is why I am going back to school, so I can hopefully do something with this talent--legally. Do you have a background in this field of any kind?
poster:Chairman_MAO
thread:313489
URL: http://www.dr-bob.org/babble/20040215/msgs/314619.html