Posted by Sad Panda on February 16, 2004, at 22:47:42
In reply to Re: RITANSERIN - availabe on earth?? » Sad Panda, posted by Chairman_MAO on February 16, 2004, at 21:35:53
> The term has been abused, but the term "SNRI" is a misleading acronym that actually means "Serotonin Norepinephrine Reuptake Inhibitor". At the doses you need to block the DA reuptake pump with Zoloft, you'd be UeberSaturating(sm) the SE reuptake pump. This is not selective. ;)
>
> I believe selective just means a 10-fold difference in binding affinity.When I said SDRI I meant Serotonin Dopamine Reuptake Inhibitor. Sertraline's affinity for blocking Dopamine reuptake is nearly as potent an Velafaxine's affinity for blocking Norepinephrine reuptake, which isn't saying much for Venlafaxine's 'dual action'.
From http://www.psychotropical.com/notes/613.html
"of the 100 or more CNS receptors currently known, not to mention ion channels and enzymes, most of these drugs have not come within experimental shouting distance of one tenth of them. So exactly what they may or may not be specific for is largely unknown."It's 4 years old, but still a valid statement.
Cheers,
Panda.
poster:Sad Panda
thread:313489
URL: http://www.dr-bob.org/babble/20040215/msgs/314406.html