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Re: aspirin and serotonin, and also opiods Larry Hoover

Posted by avid abulia on July 13, 2003, at 15:28:12

In reply to Re: aspirin and serotonin, and also opiods avid abulia, posted by Larry Hoover on July 13, 2003, at 7:16:11

> About tramadol....
> Yes, I've seen some reports of these trials, but I've never found anyone who used tramadol, and had a lasting benefit.
> The rapid-onset antidepressant effect is quite startling. Hours. But use it every day, and the antidepressant effect diminishes, perhaps over two weeks. That's my experience, and the experience of everyone I've ever talked to, who tried it.

Yes, that has been my experience on it as well. i have a bottle of the stuff around here somewhere, i occasionally use it for a PRN anti-depressant effects, for no more than three times per day for a few days at a time because it does wear off pretty quickly. But it does faff-all for pain, for me, though.

I have heard anecdotal stories from friends of mine who are heavy into junk that heroin (which, being that it is turned into morphine within 4 minutes of entering the bloodstream, induces tryptophan hydroxylase) has anti-depressant effects... but how much of that is due to the multifarious social as well as physiological effects of addiction to an illegal opiod that one self-injects, i can only guess at.





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