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Re: Need Names of Drugs Like Fentanyl juanantoniod

Posted by Larry Hoover on July 13, 2003, at 6:39:12

In reply to Re: Need Names of Drugs Like Fentanyl Larry Hoover, posted by juanantoniod on July 13, 2003, at 0:59:40

> How much should I take and how often? For example do I need to take it regularly to build up a supply in my system, or do I just take it with the pain meds?
> Thanks again for your advice!

I've never found clear recommendations about dosing, other than suggestions that 500 mg/day DLPA were helpful. You could safely double or triple that dose. One source suggests taking it alternate weeks (probably to prevent changes in regulatory activity at the receptor level). It makes sense to split the dose up, to try and maintain a consistent blood concentration, but you are best to take it on an empty stomach, for maximum uptake.


Med Hypotheses. 2000 Oct;55(4):283-8.

DL-phenylalanine markedly potentiates opiate analgesia - an example of
nutrient/pharmaceutical up-regulation of the endogenous analgesia system.

Russell AL, McCarty MF.

Brampton Pain Clinic, Bramalea, Ontario, Canada.

In the author's clinical experience, concurrent treatment with
DL-phenylalanine (DLPA) often appears to potentiate pain relief and also
ease depression in patients receiving opiates for chronic non-malignant
pain. An analysis of this phenomenon suggests that it may be mediated, at
least in part, by up-regulation of the 'endogenous analgesia system' (EAS),
a neural pathway that projects caudally from medullary nuclei to the dorsal
horn of the spinal column; when stimulated by chronic pain or therapeutic
measures such as opiates or acupuncture, the EAS suppresses activation of
second-order pain-receptive neurons in the dorsal horn, and thereby
alleviates pain. Since serotonin and enkephalins are key neurotransmitters
in the EAS, it is reasonable to predict that measures which promote
serotonin activity (such as 5-hydroxytryptophan and serotonin-reuptake
inhibitors) as well as enkephalin activity (such as D-phenylalanine, an
enkephalinase inhibitor) should potentiate EAS-mediated analgesia - a view
consistent with much previous medical research. Comprehensive support of the
EAS with well-tolerated nutrients and pharmaceuticals may amplify the
analgesic efficacy of chronic opiate therapy, while enabling dosage
reductions that minimize opiate side-effects. Analogously, this approach may
complement the efficacy of acupuncture and other analgesic measures that
activate the EAS.




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