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Re: morphine pump sepsis, and DLPA avid abulia

Posted by Juanantoniod on July 13, 2003, at 22:17:48

In reply to morphine pump sepsis, and DLPA, posted by avid abulia on July 13, 2003, at 17:44:23


About how long do you think before I can expect any noticeable change from taking the DLPA? I got the DLPA today in 750mg capsules and I took one already. BTW, I have Marinol, but I find that, as it increases the senses, it also increases my sense of pain. It also seems to counter-act any pain relieving effect of medication. These are probably just peculiar to me, of course.

Thanks again for your help!

> Morphine pumps are a dangerous game, because they are highly prone to post-surgical sepsis (that is, wound infection--morphine is an immunosupressant, and also pro-inflammatory and pro-angiogenesis)... and of course there is the issue of building up higher and higher levels of tolerance with a continuous self-regulated level of morphine in your blood supply, you can only go so far before your body just can't take any more, your opioid system blows out altogether, and you keel over dead.
> i used DLPA with good results, i had bought it in bulk powder form, and the recommended dose was 1tsp per day which was roughly equal to 2.7 grams. I ran out, though, and am a full-time student so i don't have sufficient funds to buy more at this time. D-phenylalanine has a very long half-life, because unless you are a bacterium your body is not set up to deal effectively with D isomers of amino acids (in fact, some D isomers, such as D-arginine and D-asartic acid are *highly* toxic because the body incorporates them into proteins but the proteins no longer work after that, and the body is very slow about dealing with them)... so once-daily dosing is okay for DLPA.
> Marinol (the pharmaceutical analogue of delta-9-tetrahydrocannibinol) enhances the effects of opioids in pain relief, at levels below that needed for producing marked psychological effects.
> Antihistamines are sometimes helpful, both because of peripheral anti-inflammatory effects and central anticholinergic effects.
> There are new nicotinic acetylcholine agonists in the pipeline that are even more powerful pain relievers than narcotics, without the deleterious cardiovascular effects of non-selective agonists like nicotine. However, if you don't smoke or chew tobacco, a nicotine patch might help, as well.
> Electrolyte balance has an effect on opioid tolerance as well (by effecting membrane resting-potential) and class-I antiarhythmic drugs such as Mexitil can help with opiod tolerance because of that (of course, there is the issue that they raise the risk for fatal heart attack, but everything has a price)... and Mexitil in particular has studies backing its use in mood disorders, as well.
> Well, this has about exhausted my knowledge of analgesia here.
> Best of luck.
> ~AA




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