Posted by Larry Hoover on June 12, 2003, at 11:47:08
In reply to Re: Do you think meds will help, posted by Maxime on June 12, 2003, at 10:41:13
> The Parnate helps my depression big time - like nothing before it. But even when I was in the black hole of depression, I was never suicidal. I would become almost catatonic.
>
> The mixed states however, I have been never lessened. It's during the mixed states that I am at my worse and most suicidal ... like right now.
>
> The lamictal is making me dizzy and nauseous. I will try to continue with it (since I just started) but there have been other mood stabilisers that I have had to stop because of the dizziness. It makes me walk like a drunk.
>
> I have already lost all my friends because they can't handle my mixed states and suicide attempts etc. In the end, I am all alone.
>
> I already know that I am going to die at my own hands. It's really just a question of when and how. But it is something I have known since I was child - I am now 34. I have a strong feeling that it will be this year or next.
>
> maxHave you been using fish oil, and/or B-vitamins? There are case reports of fish oil relieving suicidality. Niacinamide could have a calming effect. Have you considered your diet as a controllable factor in your well-being?
Lar
Fortschr Neurol Psychiatr. 2001 Oct;69(10):460-7.
[Cholesterol, omega-3 fatty acids, and suicide risk: empirical evidence and pathophysiological hypotheses][Article in German]
Brunner J, Parhofer KG, Schwandt P, Bronisch T.
Max-Planck-Institut fur Psychiatrie, Munchen. jbrunner@mpipsykl.mpg.de
Studies in psychiatric patients described an association between lower serum cholesterol concentrations, suicidality, depression, impulsivity, and aggression which is not entirely attributable to depression-related malnutrition and weight-loss. Several lines of evidence suggest that a serotonergic deficit in the prefrontal cortex may predispose vulnerable subjects to impulsive, autoaggressive, and suicidal behaviour in stressful life-events. In-vitro studies, animal experiments, and human in-vivo studies support the hypothesis that cholesterol reduction may contribute to the serotonergic abnormalities which have been postulated in suicidal subjects. Recently it was hypothesized that decreased consumption of polyunsaturated fatty acids, especially omega-3 fatty acids, may be a risk factor for depression and suicide. Data from human studies in healthy volunteers suggest that increasing the dietary intake of omega-3 fatty acids may increase central serotonergic activity and reduce impulsive and aggressive behaviours. Earlier epidemiological studies showed an association between low cholesterol concentrations and increased suicide risk. Recent epidemiological studies with greater samples and longer follow-up periods, however, even showed a positive correlation between cholesterol concentrations and suicide risk after controlling for potential confounding variables. Large trials of statins (simvastatin, lovastatin, pravastatin) did not show an increase of suicide mortality.
poster:Larry Hoover
thread:233294
URL: http://www.dr-bob.org/babble/20030609/msgs/233407.html