Posted by paulk on February 27, 2003, at 15:53:33
In reply to Sorry paulk, posted by JohnnyB on February 27, 2003, at 11:56:53
> Didn't mean to leave you out of the thanks. You were the first to respond, but since that was yesterday, I forgot about your message while composing
> thanks this morning. Of course yesterday was nothing but a blurr.
>Yeah – isn’t that strange – when I take too much I can’t hardly remember anything and it is hard to function – almost exactly the opposite of the good effect. It even makes it hard to decide what to do about the med itself.
>The sx seem to be lessening and the benefits (improved focus, etc.) seem to be more prominent. We'll just have to wait more to see for sure.
>Perhaps this is one way we find out if we are poor metabolizers (PMs) of CYP2D6.
>
It appears that there is a 5 fold difference in blood level depending on ones metabolism (wonder if that is just for kids – could be worse for adults?) What is an interesting coincidence is that Desipramine, which also acts in part as a SNRI, has a 35 fold range of blood-level for the same dosage. I bet you sleep tonight.>I've been reading your messages in this thread, but have seen nothing from you between 2/10 and today. You seemed happy with the earlier
>results and in today’s message you still sound pleased, yes?I’m getting more done AND my sex life is enhanced. It seems that I need to be pickier about the dosage than with other meds I’ve tried. Start low and work up slowly would seem to be good advice. They probably should change the monograph if they want wide success.
I think I felt a bit euphoric the first week – haven’t felt that good again, but overall things are good. The only other drug that gave me anything close was Nardil – this is better so far at week 3.
poster:paulk
thread:133458
URL: http://www.dr-bob.org/babble/20030224/msgs/204413.html