Posted by Ritch on February 27, 2003, at 0:27:15
In reply to Re: Don't split Strattera caps according to Lilly, posted by viridis on February 26, 2003, at 14:27:37
> I've mentioned this here before, but will repeat my experience with Wellbutrin SR. The literature says don't divide them, and people seem to think that this is because they have a slow-release coating. But when I called GSK and spoke with one of the people who actually developed the slow-release form, he said that splitting the pills was fine, and they'd even tested this quite extensively. The slow release is controlled by the wax matrix inside, which dissolves at the same rate whether split or not. When I asked why they discourage people from splitting them, he said it's just because it's hard to get accurate dosing (the pills aren't scored so don't split exactly evenly). Also, if they sit around split for days, they take up moisture from the air. But the product info makes it sound like splitting the pills will cause dire consequences. It certainly didn't for me.....
Aha! So, that's why splitting WB SR tabs results in clean cracking (little powder or dust evidently due to the wax matrix inside). The generic bupropion crumbles really easily in comparison and makes a lot of dust.
thanks for that info.
poster:Ritch
thread:133458
URL: http://www.dr-bob.org/babble/20030224/msgs/204220.html