Posted by LAURA777 on February 20, 2003, at 7:58:03
In reply to Re: TCAs and NE » fachad, posted by not exactly on February 20, 2003, at 3:39:07
> I've been taking desipramine for about 3 weeks. At first, I noticed anger, irritation, and a paradoxical _decrease_ in caring about anything pleasant or worthwhile.. Perhaps this was due to the initial NE increase.
Yes i do belive this is true !! our systems work on a ying and yang basis .. part of the calming nueros supress Ne production or increase reception .. or both ?? opioid peptides gaba are some of these nueros .. the Ne system in fight of flight and the opioid peptides work in conjuction with each other , from what i understand is , in this instance of fight or flight , the do not act independantly of each other .. But what if the opioid peptide tone is defunct ? this would explain why alcoholic and addicts have such a low threshold for the ability to deal with stress ..they also studied children of alcoholics and have seen the low threshold for stress .. little annyoyances can seem like mountains ...From what i understand of endorphins is , that when there are low levels , the primitive system of the brain keeps a tight rein on these , for emergency bodily situations , like being hit by a truck ...So little is left for the everyday living and feeling well .. this explains the push that i feel in doing everything ,i have the energy but the payoff is absent , hence your statement below
"WHY BOTHER syndrome is in full gear. I had planned to go to a party tonite, but now the thought of showering, getting dressed, and driving to it seem like far too much trouble. And what could I possibly enjoy at the party anyway? I don't want to be with people, or eat, or drink, or hear music. I just want to crawl in a hole somewhere. But I don't even feel like resting or sleeping. I don't know WHAT I want, and if I knew, it wouldn't be worth the effort"
It seems for me at least that "the excertion always outweighs the pleasure" ..
why I _haven't_ been noticing any sustained improvement in motivation, focus, and energy (which has surprised and disappointed me)?
Because absence of NE in certin areas of the brain will cause poor focus ADHD and attention span .. Is your motivation factor because of no energy ?? or because you do not feel a payoff ??? let me know , thanks laura