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Tardive dyskinesia

Posted by Jaynee on January 18, 2003, at 22:56:49

In reply to Re: getting laid isn't all there is, posted by utopizen on January 13, 2003, at 11:00:17

I am not on a AP, but I am concerned for those who take them, especially if they work for people. So here is an article on it, it almost sounds promising.

Oxidative mechanisms and tardive dyskinesia.

Lohr JB, Kuczenski R, Niculescu AB.

Department of Psychiatry, University of California San Diego, San Diego, California, USA.

Tardive dyskinesia has been and continues to be a significant problem associated with long-term antipsychotic use, but its pathophysiology remains unclear. In the last 10 years, preclinical studies of the administration of antipsychotics to animals, as well as clinical studies of oxidative processes in patients given antipsychotic medications, with and without tardive dyskinesia, have continued to support the possibility that neurotoxic free radical production may be an important consequence of antipsychotic treatment, and that such production may relate to the development of dyskinetic phenomena. In line with this hypothesis, evidence has accumulated for the efficacy of antioxidants, primarily vitamin E (alpha-tocopherol), in the treatment and prevention of tardive dyskinesia. Early studies suggested a modest effect of vitamin E treatment on existing tardive dyskinesia, but later studies did not demonstrate a significant effect. Because evidence has continued to accumulate for increased oxidative damage from antipsychotic medications, but less so for the effectiveness of vitamin E, especially in cases of long-standing tardive dyskinesia, alternative antioxidant approaches to the condition may be warranted. These approaches may include the use of antioxidants as a preventive measure for tardive dyskinesia or the use of other antioxidants or neuroprotective drugs, such as melatonin, for established tardive dyskinesia.

PMID: 12467492 [PubMed - in process]




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