Posted by Seamus2 on July 29, 2002, at 20:30:48
In reply to Re: Question for you - Xevious, posted by Xevious on July 29, 2002, at 18:06:32
From Goodman and Gilman's 1st ed. 11th printing pg 436
Benzedrine exists in three forms due to the presence of an asymmetric carbom atom, the d-, l- and dl-benzedrines. The dextrorotary form appears to be from two to four times more active than the other two isomers, as determined by clinical tests in normal individuals and in patients with nacrolepsy, postencephalitic Parkinson's disease and postural hypotension (Prinzmetal and Alles, 1939). The order of decreasing potency is as follows: d-benzedrine, racemic benzedrine, l-benzedrine. This is particularly interesting because in most instances, levorotary compounds possess considerably more pharmacodynamic activity than the dextro or racemic isomers.
If you have a wayback machine handy, you could check:
3. Alles G.A.: The comparative physiological actions of dl- -phenylisopropylamines. I. Pressor effects and toxicity. J. Pharmacol. Exp. Ther., 1933, 37, 339-354.
4. Alles G.A., Prinzmetal M.: The comparative physiological actions of dl--phenylisopropylamines. II. Bronchial effects. J. Pharmacol. Exp. Ther., 1933, 38, 161-174.Seamus
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