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Re: Question for you - Xevious

Posted by Xevious on July 25, 2002, at 12:43:14

In reply to Question for you - Xevious, posted by BekkaH on July 25, 2002, at 5:54:40

I completely agree; I think that marketing has had much to do with this issue, especially since re-labeling Obetrol allowed Shire to re-patent it, while the patent on Dexedrine (also Shire, IIRC) is long since expired. The stigma also plays a role; even though Obetrol was abused about as much as Dexedrine in years past, Adderall has given it a shiny new name.

All that said, I've been unable to find any studies confirming the d/l CNS/PNS connection. If anyone here has links or references, I'd really appreciate it if you'd post them here! I very much believe that the d and l enantiomers affect folks differently, and the anecdotal evidence I've heard and read seems to indicate that the d form is more CNS selective, but I'm not completely sold on the CNS/PNS split being so cut and dried. In my personal experience, psychopharmaceutical action rarely ever is! :)

But that's what happens when you take a shotgun approach to "fixing" such an enormously complex biochemical machine like the brain...

Another reason why Adderall is the preferred ADHD med is probably because it is 25% l enantiomer - a little nudge of PNS stimulation can really wake you up, assuming that you can tolerate the side effects. Personally, this is why I want to give Provigil a try. Theoretically, it gives more wakefulness for less side effects. (Crossing fingers, praying to the god of pharmaceuticals...)

Obviously, there is either some real scientific evidence out there (or just incredibly strong anecdotal evidence!) in favor of the d enantiomer of methylphenidate, or Focalin wouldn't have been developed.

Thanks for checking me, I do appreciate it! I'm still sorting out facts from assumptions on all of this stuff, and it's just a bit confusing! ;)

-Xevious


> >
> ************************************************
> Xevious,
> Are you sure that the CNS/PNS stimulation issue of the d and l isomers is only subjective and not scientifically proven? I've read about this in so many places, including some psychopharmacology texts, so I'm wondering whether it is just subjective.
>
> As far as Adderall being preferred by the majority of ADHD folks, I think one reason for that is that it has been so aggressively marketed in recent years. Adderall is the exact same chemical composition as a drug called Obetrol that is no longer available. Apparently it was a diet drug. Shire Pharmaceuticals bought the rights to the drug, renamed it, and aggressively packaged it for the ADHD market. The name "Adderall" has much less of a stigma attached to it than the name "amphetamine," "Dexedrine," or any of the previously available formulations (such as the above-mentioned Obetrol). By the way, my psychopharmacologist believes that of all the psychostimulants, Dexedrine is most effective for depression.
>


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poster:Xevious thread:113464
URL: http://www.dr-bob.org/babble/20020725/msgs/113686.html